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Term Information

Accession
GO:0030374
Name
nuclear receptor coactivator activity
Ontology
molecular_function
Synonyms
ligand-activated RNA polymerase II transcription factor binding transcription factor activity, ligand-dependent nuclear receptor transcription co-activator activity, ligand-dependent nuclear receptor transcription coactivator activity, nuclear receptor transcription coactivator activity, transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
Alternate IDs
GO:0038049
Definition
A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. Source: GOC:dph, GOC:tb
Comment
For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
History
See term history for GO:0030374 at QuickGO
Subset
None
Feedback
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Parents of nuclear receptor coactivator activity (GO:0030374)
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nuclear receptor coactivator activity [is_a relation] is_a  transcription coactivator activity (GO:0003713)

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