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type I site-specific deoxyribonuclease complex

Term Information

Accession
GO:0019812
Name
type I site-specific deoxyribonuclease complex
Ontology
cellular_component
Synonyms
type I restriction enzyme complex
Alternate IDs
None
Definition
A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell. Source: PMID:15788748, PMID:12654995
Comment
None
History
See term history for GO:0019812 at QuickGO
Subset
None
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Graph of GO:0019812

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Parents of type I site-specific deoxyribonuclease complex (GO:0019812)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
type I site-specific deoxyribonuclease complex [is_a relation] is_a  endodeoxyribonuclease complex (GO:1905347)
type I site-specific deoxyribonuclease complex [BFO:0000050 relation] BFO:0000050  cytoplasm (GO:0005737)

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