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Term Information

Accession
GO:0019643
Name
reductive tricarboxylic acid cycle
Ontology
biological_process
Synonyms
reductive Kreb's cycle, reductive TCA cycle, reductive carboxylate cycle, reductive carboxylic acid cycle, reductive citric acid pathway
Alternate IDs
GO:0019644
Definition
A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. Source: PMID:15838028, GOC:jl
Comment
None
History
See term history for GO:0019643 at QuickGO
Subset
None
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Graph of GO:0019643

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Parents of reductive tricarboxylic acid cycle (GO:0019643)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
reductive tricarboxylic acid cycle [is_a relation] is_a  carbon fixation (GO:0015977)
reductive tricarboxylic acid cycle [is_a relation] is_a  tricarboxylic acid cycle (GO:0006099)

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MetaCyc
REDCITCYC
P23-PWY