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Term Information

Accession
GO:0016592
Name
mediator complex
Ontology
cellular_component
Synonyms
L mediator complex, Srb-mediator complex, CDK8-containing TRAP/mediator complex, TRAP complex
Alternate IDs
GO:0000119
Definition
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:16168358, PMID:11454195, PMID:17870225
Comment
None
History
See term history for GO:0016592 at QuickGO
Subset
None
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Graph of GO:0016592

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Parents of mediator complex (GO:0016592)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mediator complex [BFO:0000051 relation] BFO:0000051  core mediator complex (GO:0070847)
mediator complex [is_a relation] is_a  protein-containing complex (GO:0032991)
mediator complex [BFO:0000050 relation] BFO:0000050  nucleoplasm (GO:0005654)

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