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Term Information

Accession
GO:0010629
Name
negative regulation of gene expression
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. Source: GOC:dph, GOC:tb
Comment
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
History
See term history for GO:0010629 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0010629

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Parents of negative regulation of gene expression (GO:0010629)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of gene expression [RO:0002212 relation] RO:0002212  gene expression (GO:0010467)
negative regulation of gene expression [is_a relation] is_a  negative regulation of macromolecule metabolic process (GO:0010605)
negative regulation of gene expression [is_a relation] is_a  regulation of gene expression (GO:0010468)
Children of negative regulation of gene expression (GO:0010629)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of RNA splicing (GO:0033119) [is_a relation] is_a  negative regulation of gene expression
negative regulation of snoRNA processing (GO:1902797) [is_a relation] is_a  negative regulation of gene expression
negative regulation of tRNA processing (GO:2000236) [is_a relation] is_a  negative regulation of gene expression
negative regulation of cytokine production (GO:0001818) [is_a relation] is_a  negative regulation of gene expression
negative regulation of histone gene expression (GO:0036208) [is_a relation] is_a  negative regulation of gene expression
gene silencing (GO:0016458) [is_a relation] is_a  negative regulation of gene expression
mRNA catabolic process (GO:0006402) [is_a relation] is_a  negative regulation of gene expression
negative regulation of transcription, DNA-templated (GO:0045892) [is_a relation] is_a  negative regulation of gene expression
suppression by virus of host gene expression (GO:0039657) [is_a relation] is_a  negative regulation of gene expression
negative regulation of rRNA processing (GO:2000233) [is_a relation] is_a  negative regulation of gene expression
negative regulation of gene expression, epigenetic (GO:0045814) [is_a relation] is_a  negative regulation of gene expression
negative regulation of protein maturation (GO:1903318) [is_a relation] is_a  negative regulation of gene expression
negative regulation of translation (GO:0017148) [is_a relation] is_a  negative regulation of gene expression
negative regulation of rhodopsin gene expression (GO:0045871) [is_a relation] is_a  negative regulation of gene expression
pericentric heterochromatin assembly (GO:0031508) [is_a relation] is_a  negative regulation of gene expression
negative regulation of production of miRNAs involved in gene silencing by miRNA (GO:1903799) [is_a relation] is_a  negative regulation of gene expression
negative regulation of production of siRNA involved in RNA interference (GO:1903704) [is_a relation] is_a  negative regulation of gene expression
None.