Planteome: Term Details for "IkappaB kinase complex" (GO:0008385)

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Term Information

Accession: GO:0008385
Name: IkappaB kinase complex
Ontology: cellular_component
Synonyms: IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Alternate IDs: None
Definition: A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:bf, GOC:ma, PMID:20300203, PMID:12055104
Comment: None
History: See term history for GO:0008385 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to IkappaB kinase complex.; Link to all direct and indirect annotations to IkappaB kinase complex.; Link to all direct and indirect annotations download (limited to first 10,000) for IkappaB kinase complex.
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