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Term Information

Accession
GO:0008384
Name
IkappaB kinase activity
Ontology
molecular_function
Synonyms
ATP:IkappaB protein phosphotransferase activity, CHUK, IKBKA, IKBKB, IKK, IKK-1, IKK-2, STK12, TBK1, ikappaB kinase activity, inhibitor of NF-kappaB kinase activity, inhibitor of NFkappaB kinase activity, TANK-binding kinase 1 activity
Alternate IDs
None
Definition
Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. Source: EC:2.7.11.10
Comment
Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
History
See term history for GO:0008384 at QuickGO
Subset
None
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Graph of GO:0008384

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Parents of IkappaB kinase activity (GO:0008384)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase activity [is_a relation] is_a  protein serine/threonine kinase activity (GO:0004674)
IkappaB kinase activity [BFO:0000050 relation] BFO:0000050  I-kappaB phosphorylation (GO:0007252)

This term has no children.