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Term Information

Accession
GO:0008219
Name
cell death
Ontology
biological_process
Synonyms
accidental cell death, necrosis
Alternate IDs
None
Definition
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). Source: PMID:25236395, GOC:mah, GOC:mtg_apoptosis
Comment
This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
History
See term history for GO:0008219 at QuickGO
Subset
goslim_drosophila
goslim_chembl
goslim_generic
goslim_plant
goslim_mouse
goslim_agr
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Graph of GO:0008219

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Parents of cell death (GO:0008219)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cell death [is_a relation] is_a  cellular process (GO:0009987)
Children of cell death (GO:0008219)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neuron death (GO:0070997) [is_a relation] is_a  cell death
cell death in response to oxidative stress (GO:0036473) [is_a relation] is_a  cell death
programmed cell death (GO:0012501) [is_a relation] is_a  cell death
regulation of cell death (GO:0010941) [RO:0002211 relation] RO:0002211  cell death
negative regulation of cell death (GO:0060548) [RO:0002212 relation] RO:0002212  cell death
necrotic cell death (GO:0070265) [is_a relation] is_a  cell death
positive regulation of cell death (GO:0010942) [RO:0002213 relation] RO:0002213  cell death
None.