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Term Information

Accession
GO:0007259
Name
receptor signaling pathway via JAK-STAT
Ontology
biological_process
Synonyms
JAK-STAT signal transduction, JAK-STAT cascade
Alternate IDs
None
Definition
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. Source: GOC:signaling, GOC:jl, GOC:bf, PMID:12039028
Comment
None
History
See term history for GO:0007259 at QuickGO
Subset
None
Feedback
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Graph of GO:0007259

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Parents of receptor signaling pathway via JAK-STAT (GO:0007259)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
receptor signaling pathway via JAK-STAT [is_a relation] is_a  receptor signaling pathway via STAT (GO:0097696)
Children of receptor signaling pathway via JAK-STAT (GO:0007259)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
tyrosine phosphorylation of STAT protein (GO:0007260) [BFO:0000050 relation] BFO:0000050  receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427) [RO:0002213 relation] RO:0002213  receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426) [RO:0002212 relation] RO:0002212  receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via JAK-STAT (GO:0046425) [RO:0002211 relation] RO:0002211  receptor signaling pathway via JAK-STAT