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Term Information

Accession
GO:0007254
Name
JNK cascade
Ontology
biological_process
Synonyms
c-Jun N-terminal kinase cascade, JNK1 cascade, JNK2 cascade, JNK3 cascade, MAPK10 cascade, MAPK8 cascade, MAPK9 cascade, SAPK cascade, stress-activated protein kinase cascade
Alternate IDs
None
Definition
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. Source: GOC:signaling, PMID:11790549, PMID:20811974, GOC:bf
Comment
None
History
See term history for GO:0007254 at QuickGO
Subset
None
Feedback
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Graph of GO:0007254

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Parents of JNK cascade (GO:0007254)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
JNK cascade [is_a relation] is_a  stress-activated MAPK cascade (GO:0051403)
Children of JNK cascade (GO:0007254)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of JNK cascade (GO:0046328) [RO:0002211 relation] RO:0002211  JNK cascade
negative regulation of JNK cascade (GO:0046329) [RO:0002212 relation] RO:0002212  JNK cascade
JUN phosphorylation (GO:0007258) [BFO:0000050 relation] BFO:0000050  JNK cascade
activation of JUN kinase activity (GO:0007257) [BFO:0000050 relation] BFO:0000050  JNK cascade
activation of JNKKK activity (GO:0042655) [BFO:0000050 relation] BFO:0000050  JNK cascade
activation of JNKK activity (GO:0007256) [BFO:0000050 relation] BFO:0000050  JNK cascade
non-canonical Wnt signaling pathway via JNK cascade (GO:0038031) [BFO:0000051 relation] BFO:0000051  JNK cascade
positive regulation of JNK cascade (GO:0046330) [RO:0002213 relation] RO:0002213  JNK cascade
None.