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Term Information

Accession
GO:0007252
Name
I-kappaB phosphorylation
Ontology
biological_process
Synonyms
IKB phosphorylation, IkappaB phosphorylation, inhibitor of NF-kappaB phosphorylation, inhibitor of kappaB phosphorylation
Alternate IDs
None
Definition
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:7594468, GOC:jl, GOC:bf, PMID:21772278
Comment
None
History
See term history for GO:0007252 at QuickGO
Subset
None
Feedback
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Graph of GO:0007252

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Parents of I-kappaB phosphorylation (GO:0007252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB phosphorylation [BFO:0000050 relation] BFO:0000050  I-kappaB kinase/NF-kappaB signaling (GO:0007249)
I-kappaB phosphorylation [is_a relation] is_a  protein phosphorylation (GO:0006468)
Children of I-kappaB phosphorylation (GO:0007252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase activity (GO:0008384) [BFO:0000050 relation] BFO:0000050  I-kappaB phosphorylation
positive regulation of I-kappaB phosphorylation (GO:1903721) [RO:0002213 relation] RO:0002213  I-kappaB phosphorylation
regulation of I-kappaB phosphorylation (GO:1903719) [RO:0002211 relation] RO:0002211  I-kappaB phosphorylation
negative regulation of I-kappaB phosphorylation (GO:1903720) [RO:0002212 relation] RO:0002212  I-kappaB phosphorylation
None.