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Term Information

Accession
GO:0007249
Name
I-kappaB kinase/NF-kappaB signaling
Ontology
biological_process
Synonyms
I-kappaB kinase/NF-kappaB signal transduction, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, activation of the inhibitor of kappa kinase, p50-dependent NF-kappaB signaling, NF-kappaB cascade
Alternate IDs
None
Definition
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:12773372, GOC:jl, GOC:bf, Reactome:R-HSA-209560
Comment
None
History
See term history for GO:0007249 at QuickGO
Subset
None
Feedback
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Graph of GO:0007249

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Parents of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB kinase/NF-kappaB signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
I-kappaB kinase/NF-kappaB signaling [BFO:0000051 relation] BFO:0000051  positive regulation of NF-kappaB transcription factor activity (GO:0051092)
Children of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) [RO:0002213 relation] RO:0002213  I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) [RO:0002211 relation] RO:0002211  I-kappaB kinase/NF-kappaB signaling
epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade (GO:0038168) [BFO:0000051 relation] BFO:0000051  I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124) [RO:0002212 relation] RO:0002212  I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation (GO:0007252) [BFO:0000050 relation] BFO:0000050  I-kappaB kinase/NF-kappaB signaling
None.