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Term Information

Accession
GO:0007174
Name
epidermal growth factor catabolic process
Ontology
biological_process
Synonyms
EGF breakdown, EGF catabolism, epidermal growth factor breakdown, epidermal growth factor catabolism, EGF receptor ligand processing, epidermal growth factor ligand processing, intracellular EGF processing, receptor-mediated EGF processing
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. Source: GOC:signaling, PMID:2985587, GOC:bf
Comment
This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
History
See term history for GO:0007174 at QuickGO
Subset
None
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Graph of GO:0007174

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Parents of epidermal growth factor catabolic process (GO:0007174)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
epidermal growth factor catabolic process [is_a relation] is_a  negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)
epidermal growth factor catabolic process [is_a relation] is_a  cellular protein catabolic process (GO:0044257)

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