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Term Information

Accession
GO:0006915
Name
apoptotic process
Ontology
biological_process
Synonyms
apoptotic cell death, apoptotic programmed cell death, programmed cell death by apoptosis, apoptosis activator activity, caspase-dependent programmed cell death, commitment to apoptosis, induction of apoptosis, induction of apoptosis by p53, signaling (initiator) caspase activity, activation of apoptosis, apoptosis, apoptosis signaling, apoptotic program, type I programmed cell death, cell suicide, cellular suicide
Alternate IDs
GO:0006917, GO:0008632
Definition
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. Source: GOC:tb, ISBN:0198506732, PMID:21494263, GOC:go_curators, GOC:mtg_apoptosis, GOC:cjm, GOC:ecd, PMID:18846107, GOC:dhl
Comment
None
History
See term history for GO:0006915 at QuickGO
Subset
goslim_pombe
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0006915

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Parents of apoptotic process (GO:0006915)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic process [is_a relation] is_a  programmed cell death (GO:0012501)
Children of apoptotic process (GO:0006915)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
fat cell apoptotic process (GO:1904606) [is_a relation] is_a  apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153) [BFO:0000050 relation] BFO:0000050  apoptotic process
apoptotic signaling pathway (GO:0097190) [BFO:0000050 relation] BFO:0000050  apoptotic process
hepatoblast apoptotic process (GO:1902489) [is_a relation] is_a  apoptotic process
apoptotic process in response to mitochondrial fragmentation (GO:0140208) [is_a relation] is_a  apoptotic process
anoikis (GO:0043276) [is_a relation] is_a  apoptotic process
muscle cell apoptotic process (GO:0010657) [is_a relation] is_a  apoptotic process
myofibroblast cell apoptotic process (GO:1904516) [is_a relation] is_a  apoptotic process
cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027) [BFO:0000050 relation] BFO:0000050  apoptotic process
glial cell apoptotic process (GO:0034349) [is_a relation] is_a  apoptotic process
peptidase activator activity involved in apoptotic process (GO:0016505) [BFO:0000050 relation] BFO:0000050  apoptotic process
regulation of apoptotic process (GO:0042981) [RO:0002211 relation] RO:0002211  apoptotic process
epithelial cell apoptotic process (GO:1904019) [is_a relation] is_a  apoptotic process
neuron apoptotic process (GO:0051402) [is_a relation] is_a  apoptotic process
leukocyte apoptotic process (GO:0071887) [is_a relation] is_a  apoptotic process
apoptotic process involved in development (GO:1902742) [is_a relation] is_a  apoptotic process
apoptotic process in bone marrow cell (GO:0071839) [is_a relation] is_a  apoptotic process
fibroblast apoptotic process (GO:0044346) [is_a relation] is_a  apoptotic process
execution phase of apoptosis (GO:0097194) [BFO:0000050 relation] BFO:0000050  apoptotic process
positive regulation of apoptotic process (GO:0043065) [RO:0002213 relation] RO:0002213  apoptotic process
retinal cell apoptotic process (GO:1990009) [is_a relation] is_a  apoptotic process
melanocyte apoptotic process (GO:1902362) [is_a relation] is_a  apoptotic process
inflammatory cell apoptotic process (GO:0006925) [is_a relation] is_a  apoptotic process
myeloid cell apoptotic process (GO:0033028) [is_a relation] is_a  apoptotic process
mesenchymal cell apoptotic process (GO:0097152) [is_a relation] is_a  apoptotic process
negative regulation of apoptotic process (GO:0043066) [RO:0002212 relation] RO:0002212  apoptotic process
apoptotic mitochondrial changes (GO:0008637) [BFO:0000050 relation] BFO:0000050  apoptotic process
Wikipedia
Apoptosis