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Term Information

Accession
GO:0006289
Name
nucleotide-excision repair
Ontology
biological_process
Synonyms
NER, pyrimidine-dimer repair, DNA damage excision, intrastrand cross-link repair
Alternate IDs
GO:0045001
Definition
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). Source: PMID:10197977
Comment
Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
History
See term history for GO:0006289 at QuickGO
Subset
None
Feedback
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Graph of GO:0006289

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Parents of nucleotide-excision repair (GO:0006289)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nucleotide-excision repair [is_a relation] is_a  DNA repair (GO:0006281)
Children of nucleotide-excision repair (GO:0006289)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription-coupled nucleotide-excision repair (GO:0006283) [is_a relation] is_a  nucleotide-excision repair
global genome nucleotide-excision repair (GO:0070911) [is_a relation] is_a  nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition (GO:0000715) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
nucleotide-excision repair involved in interstrand cross-link repair (GO:1901255) [is_a relation] is_a  nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly (GO:0006294) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
nucleotide-excision repair, DNA duplex unwinding (GO:0000717) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
nucleotide-excision repair, DNA damage removal (GO:0000718) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization (GO:0006293) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
regulation of nucleotide-excision repair (GO:2000819) [RO:0002211 relation] RO:0002211  nucleotide-excision repair
nucleotide-excision repair, DNA incision (GO:0033683) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
pyrimidine dimer repair by nucleotide-excision repair (GO:0000720) [is_a relation] is_a  nucleotide-excision repair
nucleotide-excision repair, DNA gap filling (GO:0006297) [BFO:0000050 relation] BFO:0000050  nucleotide-excision repair
None.