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Term Information

Accession
GO:0005967
Name
mitochondrial pyruvate dehydrogenase complex
Ontology
cellular_component
Synonyms
pyruvate dehydrogenase complex (lipoamide)
Alternate IDs
None
Definition
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. Source: ISBN:0471331309, GOC:mtg_sensu, ISBN:0716720094
Comment
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
History
See term history for GO:0005967 at QuickGO
Subset
None
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Graph of GO:0005967

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Parents of mitochondrial pyruvate dehydrogenase complex (GO:0005967)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitochondrial pyruvate dehydrogenase complex [BFO:0000050 relation] BFO:0000050  mitochondrial matrix (GO:0005759)
mitochondrial pyruvate dehydrogenase complex [is_a relation] is_a  mitochondrial protein complex (GO:0098798)
mitochondrial pyruvate dehydrogenase complex [BFO:0000050 relation] BFO:0000050  mitochondrion (GO:0005739)
mitochondrial pyruvate dehydrogenase complex [is_a relation] is_a  pyruvate dehydrogenase complex (GO:0045254)

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