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Term Information

Accession
GO:0004879
Name
nuclear receptor activity
Ontology
molecular_function
Synonyms
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-dependent nuclear receptor activity, ligand-dependent transcription factor activity, nuclear receptor activity, 1,25-(OH)2D3 receptor activity, 9-cis retinoic acid receptor activity, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding, RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding, RXR, androgen receptor activity, calcitriol receptor activity, ecdysteroid hormone receptor activity, estrogen nuclear receptor activity, glucocorticoid receptor activity, juvenile hormone receptor activity, nuclear hormone receptor, retinoic acid receptor activity, retinoid-X receptor activity, thyroid hormone receptor activity, vitamin A receptor activity, vitamin D receptor activity, vitamin D3 receptor activity
Alternate IDs
GO:0038052, GO:0038050, GO:0038051, GO:0004886, GO:0004887, GO:0004884, GO:0004882, GO:0004880, GO:0003708, GO:0008434
Definition
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to modulate transcription by RNA polymerase II. Source: GOC:signaling, GOC:txnOH-2018
Comment
GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'nuclear receptor transcription coactivator activity ; GO:0030374'.
History
See term history for GO:0004879 at QuickGO
Subset
None
Feedback
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Graph of GO:0004879

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Parents of nuclear receptor activity (GO:0004879)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear receptor activity [BFO:0000050 relation] BFO:0000050  intracellular receptor signaling pathway (GO:0030522)
nuclear receptor activity [is_a relation] is_a  DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)
nuclear receptor activity [is_a relation] is_a  ligand-activated transcription factor activity (GO:0098531)
Children of nuclear receptor activity (GO:0004879)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of androgen receptor activity (GO:2000825) [RO:0002213 relation] RO:0002213  nuclear receptor activity
None.