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Term Information

Accession
GO:0004839
Name
ubiquitin activating enzyme activity
Ontology
molecular_function
Synonyms
E1 ubiquitin-activating enzyme
Alternate IDs
None
Definition
Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. Source: GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme
Comment
The ubiquitin activating enzyme catalyzes a ligation reaction.
History
See term history for GO:0004839 at QuickGO
Subset
None
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Graph of GO:0004839

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Parents of ubiquitin activating enzyme activity (GO:0004839)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ubiquitin activating enzyme activity [is_a relation] is_a  ubiquitin-like modifier activating enzyme activity (GO:0008641)
ubiquitin activating enzyme activity [BFO:0000050 relation] BFO:0000050  protein ubiquitination (GO:0016567)

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