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Term Information

Accession
GO:0004489
Name
methylenetetrahydrofolate reductase (NAD(P)H) activity
Ontology
molecular_function
Synonyms
5,10-methylenetetrahydrofolate reductase (FADH) activity, 5,10-methylenetetrahydrofolate reductase (FADH2) activity, 5,10-CH(2)-H(4)folate reductase activity, 5,10-CH2-H4folate reductase activity, 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity, 5,10-methylenetetrahydrofolate reductase (NADPH) activity, 5,10-methylenetetrahydropteroylglutamate reductase activity, 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity, 5-methyltetrahydrofolate:NAD oxidoreductase activity, 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity, 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity, 5-methyltetrahydrofolate:NAD+ oxidoreductase activity, 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity, 5-methyltetrahydrofolate:NADP+ oxidoreductase activity, MetF, N5,10-methylenetetrahydrofolate reductase activity, N5,N10-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity, methylenetetrahydrofolate reductase (NADPH(2)) activity, methylenetetrahydrofolate reductase (NADPH2), methylenetetrahydrofolate reductase [NAD(P)H], 5,10-methylenetetrahydrofolate reductase activity, 5,10-methylenetetrahydrofolic acid reductase activity, MTHFR activity, N(5),N(10)-methylenetetrahydrofolate reductase activity, N(5,10)-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate reductase activity, methylenetetrahydrofolic acid reductase activity
Alternate IDs
GO:0008702
Definition
Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. Source: PMID:26872964, EC:1.5.1.20
Comment
None
History
See term history for GO:0004489 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0004489

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Parents of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
methylenetetrahydrofolate reductase (NAD(P)H) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)
Children of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903868) [RO:0002211 relation] RO:0002211  methylenetetrahydrofolate reductase (NAD(P)H) activity
negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903869) [RO:0002212 relation] RO:0002212  methylenetetrahydrofolate reductase (NAD(P)H) activity
positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903870) [RO:0002213 relation] RO:0002213  methylenetetrahydrofolate reductase (NAD(P)H) activity
methylenetetrahydrofolate reductase NADH activity (GO:0106312) [is_a relation] is_a  methylenetetrahydrofolate reductase (NAD(P)H) activity
methylenetetrahydrofolate reductase NADPH activity (GO:0106313) [is_a relation] is_a  methylenetetrahydrofolate reductase (NAD(P)H) activity
EC
1.5.1.20
KEGG_REACTION
R01224
R07168
MetaCyc
1.5.1.20-RXN
Reactome
R-HSA-200676