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Term Information

Accession
GO:0004473
Name
malate dehydrogenase (decarboxylating) (NADP+) activity
Ontology
molecular_function
Synonyms
'malic' enzyme, (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating), L-malate:NADP oxidoreductase activity, NADP-linked decarboxylating malic enzyme, NADP-malic enzyme activity, NADP-specific malate dehydrogenase activity, NADP-specific malic enzyme, malate dehydrogenase (NADP, decarboxylating), malate dehydrogenase (decarboxylating, NADP)
Alternate IDs
None
Definition
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Source: EC:1.1.1.40
Comment
For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
History
See term history for GO:0004473 at QuickGO
Subset
None
Feedback
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Graph of GO:0004473

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Parents of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
malate dehydrogenase (decarboxylating) (NADP+) activity [is_a relation] is_a  malic enzyme activity (GO:0004470)
malate dehydrogenase (decarboxylating) (NADP+) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)
Children of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903218) [RO:0002211 relation] RO:0002211  malate dehydrogenase (decarboxylating) (NADP+) activity
positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903220) [RO:0002213 relation] RO:0002213  malate dehydrogenase (decarboxylating) (NADP+) activity
negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903219) [RO:0002212 relation] RO:0002212  malate dehydrogenase (decarboxylating) (NADP+) activity
EC
1.1.1.40
KEGG_REACTION
R00216
MetaCyc
MALIC-NADP-RXN
Reactome
R-HSA-9012349
R-HSA-9012036
RHEA
18253