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Term Information

Accession
GO:0004420
Name
hydroxymethylglutaryl-CoA reductase (NADPH) activity
Ontology
molecular_function
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, HMG-CoA reductase activity
Alternate IDs
None
Definition
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. Source: RHEA:15989, EC:1.1.1.34
Comment
None
History
See term history for GO:0004420 at QuickGO
Subset
None
Feedback
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Graph of GO:0004420

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Parents of hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:0004420)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hydroxymethylglutaryl-CoA reductase (NADPH) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)
Children of hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:0004420)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:1900490) [RO:0002213 relation] RO:0002213  hydroxymethylglutaryl-CoA reductase (NADPH) activity
negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:2001216) [RO:0002212 relation] RO:0002212  hydroxymethylglutaryl-CoA reductase (NADPH) activity
regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:2001215) [RO:0002211 relation] RO:0002211  hydroxymethylglutaryl-CoA reductase (NADPH) activity
EC
1.1.1.34
KEGG_REACTION
R02082
MetaCyc
1.1.1.34-RXN
Reactome
R-HSA-191352
RHEA
15989