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Term Information

Accession
GO:0004418
Name
hydroxymethylbilane synthase activity
Ontology
molecular_function
Synonyms
(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity, (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing), HMB-synthase activity, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase activity, porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing), pre-uroporphyrinogen synthase activity, uroporphyrinogen synthase activity, uroporphyrinogen synthetase activity, uroporphyrinogen I synthase activity, uroporphyrinogen I synthetase activity
Alternate IDs
None
Definition
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). Source: RHEA:13185, EC:2.5.1.61
Comment
Note that this function was formerly EC:4.3.1.8.
History
See term history for GO:0004418 at QuickGO
Subset
None
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Graph of GO:0004418

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Parents of hydroxymethylbilane synthase activity (GO:0004418)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hydroxymethylbilane synthase activity [is_a relation] is_a  transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)

This term has no children.

EC
2.5.1.61
KEGG_REACTION
R00084
MetaCyc
OHMETHYLBILANESYN-RXN
Reactome
R-HSA-189406
RHEA
13185