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Term Information

Accession
GO:0004129
Name
cytochrome-c oxidase activity
Ontology
molecular_function
Synonyms
cytochrome c oxidase activity, NADH cytochrome c oxidase, complex IV (mitochondrial electron transport) activity, cytochrome oxidase activity, warburg's respiratory enzyme activity, aa3-type cytochrome c oxidase, ba3-type cytochrome c oxidase, caa3-type cytochrome c oxidase, cbb3-type cytochrome c oxidase, cytochrome a3 activity, cytochrome aa3 activity, ferrocytochrome c oxidase, ferrocytochrome-c:oxygen oxidoreductase, indophenol oxidase, indophenolase
Alternate IDs
None
Definition
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. Source: EC:1.9.3.1
Comment
The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
History
See term history for GO:0004129 at QuickGO
Subset
None
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Graph of GO:0004129

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Parents of cytochrome-c oxidase activity (GO:0004129)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cytochrome-c oxidase activity [is_a relation] is_a  oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor (GO:0016676)
cytochrome-c oxidase activity [is_a relation] is_a  proton transmembrane transporter activity (GO:0015078)
cytochrome-c oxidase activity [is_a relation] is_a  heme-copper terminal oxidase activity (GO:0015002)
cytochrome-c oxidase activity [is_a relation] is_a  electron transfer activity (GO:0009055)
Children of cytochrome-c oxidase activity (GO:0004129)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of cytochrome-c oxidase activity (GO:1905376) [RO:0002212 relation] RO:0002212  cytochrome-c oxidase activity
regulation of cytochrome-c oxidase activity (GO:1904959) [RO:0002211 relation] RO:0002211  cytochrome-c oxidase activity
positive regulation of cytochrome-c oxidase activity (GO:1904960) [RO:0002213 relation] RO:0002213  cytochrome-c oxidase activity