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Term Information

Accession
GO:0003810
Name
protein-glutamine gamma-glutamyltransferase activity
Ontology
molecular_function
Synonyms
TGase activity, fibrinoligase activity, transglutaminase activity, R-glutaminyl-peptide:amine gamma-glutamyl transferase activity, factor XIIIa, fibrin stabilizing factor, glutaminylpeptide gamma-glutamyltransferase activity, polyamine transglutaminase activity, protein-glutamine:amine gamma-glutamyltransferase, tissue transglutaminase
Alternate IDs
None
Definition
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. Source: EC:2.3.2.13, RESID:AA0124
Comment
None
History
See term history for GO:0003810 at QuickGO
Subset
None
Feedback
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Graph of GO:0003810

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Parents of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein-glutamine gamma-glutamyltransferase activity [is_a relation] is_a  transferase activity, transferring amino-acyl groups (GO:0016755)
Children of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150075) [RO:0002212 relation] RO:0002212  protein-glutamine gamma-glutamyltransferase activity
positive regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150074) [RO:0002213 relation] RO:0002213  protein-glutamine gamma-glutamyltransferase activity
cornified envelope assembly (GO:1903575) [BFO:0000051 relation] BFO:0000051  protein-glutamine gamma-glutamyltransferase activity
regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150073) [RO:0002211 relation] RO:0002211  protein-glutamine gamma-glutamyltransferase activity
EC
2.3.2.13
MetaCyc
2.3.2.13-RXN
Reactome
R-HSA-140851
R-HSA-6810894
RESID
AA0124
RHEA
54816