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Term Information

Accession
GO:0003714
Name
transcription corepressor activity
Ontology
molecular_function
Synonyms
transcription co-repressor activity, transcription corepressor activity, RNA polymerase II transcription co-repressor activity, RNA polymerase II transcription corepressor activity
Alternate IDs
GO:0001106
Definition
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867
Comment
None
History
See term history for GO:0003714 at QuickGO
Subset
None
Feedback
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Graph of GO:0003714

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Parents of transcription corepressor activity (GO:0003714)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription corepressor activity [BFO:0000050 relation] BFO:0000050  negative regulation of nucleic acid-templated transcription (GO:1903507)
transcription corepressor activity [is_a relation] is_a  transcription coregulator activity (GO:0003712)
Children of transcription corepressor activity (GO:0003714)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
sigma factor antagonist activity (GO:0016989) [is_a relation] is_a  transcription corepressor activity
None.