Planteome: Term Details for "DNA-binding transcription factor activity" (GO:0003700)

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Term Information

Accession: GO:0003700
Name: DNA-binding transcription factor activity
Ontology: molecular_function
Synonyms: DNA binding transcription factor activity, gene-specific transcription factor activity, sequence-specific DNA binding transcription factor activity, bacterial-type DNA binding transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding, transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding, transcription factor activity, metal ion regulated sequence-specific DNA binding, nucleic acid binding transcription factor activity, transcription factor activity
Alternate IDs: GO:0001071, GO:0001204, GO:0001199, GO:0001131, GO:0000130, GO:0001151, GO:0001130
Definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. Source: GOC:txnOH-2018
Comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
History: See term history for GO:0003700 at QuickGO
Subset: goslim_metagenomics; goslim_chembl; goslim_drosophila; goslim_plant; goslim_mouse; goslim_agr; goslim_candida; goslim_yeast
Related: Link to all annotated objects annotated to DNA-binding transcription factor activity.; Link to all direct and indirect annotations to DNA-binding transcription factor activity.; Link to all direct and indirect annotations download (limited to first 10,000) for DNA-binding transcription factor activity.
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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GO:0008150 biological_process
GO:0044237 cellular metabolic process
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
BFO:0000015 process
GO:0065007 biological regulation
GO:0009058 biosynthetic process
GO:0006725 cellular aromatic compound metabolic process
GO:0044249 cellular biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0009987 cellular process
GO:0046483 heterocycle metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0050789 regulation of biological process
GO:0019222 regulation of metabolic process
GO:0019438 aromatic compound biosynthetic process
GO:0044271 cellular nitrogen compound biosynthetic process
BFO:0000001 entity
GO:0018130 heterocycle biosynthetic process
GO:0090304 nucleic acid metabolic process
BFO:0000003 occurrent
GO:1901362 organic cyclic compound biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0050794 regulation of cellular process
GO:0051171 regulation of nitrogen compound metabolic process
GO:0080090 regulation of primary metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0009889 regulation of biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0010467 gene expression
GO:0031326 regulation of cellular biosynthetic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0003674 molecular_function
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0006355 regulation of DNA-templated transcription
GO:0140110 transcription regulator activity
GO:0003700 DNA-binding transcription factor activity
GO:0001216 DNA-binding transcription activator activity
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001217 DNA-binding transcription repressor activity
GO:0098531 ligand-activated transcription factor activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0016987 sigma factor activity

Parents of DNA-binding transcription factor activity (GO:0003700)

subject	relation	object
DNA-binding transcription factor activity	is_a	transcription regulator activity (GO:0140110)
DNA-binding transcription factor activity	BFO:0000051	transcription cis-regulatory region binding (GO:0000976)
DNA-binding transcription factor activity	BFO:0000050	regulation of DNA-templated transcription (GO:0006355)

Children of DNA-binding transcription factor activity (GO:0003700)

subject	relation	object
DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)	is_a	DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity (GO:0051090)	RO:0002211	DNA-binding transcription factor activity
ligand-activated transcription factor activity (GO:0098531)	is_a	DNA-binding transcription factor activity
DNA-binding transcription repressor activity (GO:0001217)	is_a	DNA-binding transcription factor activity
negative regulation of DNA-binding transcription factor activity (GO:0043433)	RO:0002212	DNA-binding transcription factor activity
sigma factor activity (GO:0016987)	is_a	DNA-binding transcription factor activity
positive regulation of DNA-binding transcription factor activity (GO:0051091)	RO:0002213	DNA-binding transcription factor activity
DNA-binding transcription activator activity (GO:0001216)	is_a	DNA-binding transcription factor activity