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Term Information

Accession
GO:0002224
Name
toll-like receptor signaling pathway
Ontology
biological_process
Synonyms
TLR signaling pathway, toll-like receptor signalling pathway
Alternate IDs
None
Definition
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. Source: PMID:12467241, PMID:12524386, PMID:15585605, ISBN:0781735149, PMID:15728447, GOC:add, GO_REF:0000022, PMID:12855817
Comment
Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
History
See term history for GO:0002224 at QuickGO
Subset
None
Feedback
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Graph of GO:0002224

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Parents of toll-like receptor signaling pathway (GO:0002224)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
toll-like receptor signaling pathway [is_a relation] is_a  pattern recognition receptor signaling pathway (GO:0002221)
Children of toll-like receptor signaling pathway (GO:0002224)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MyD88-independent toll-like receptor signaling pathway (GO:0002756) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 8 signaling pathway (GO:0034158) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 10 signaling pathway (GO:0034166) [is_a relation] is_a  toll-like receptor signaling pathway
regulation of toll-like receptor signaling pathway (GO:0034121) [RO:0002211 relation] RO:0002211  toll-like receptor signaling pathway
TIRAP-dependent toll-like receptor signaling pathway (GO:0035664) [is_a relation] is_a  toll-like receptor signaling pathway
negative regulation of toll-like receptor signaling pathway (GO:0034122) [RO:0002212 relation] RO:0002212  toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway (GO:0034142) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 21 signaling pathway (GO:0035682) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 12 signaling pathway (GO:0034174) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 15 signaling pathway (GO:0035681) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway (GO:0034134) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 6 signaling pathway (GO:0034150) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 13 signaling pathway (GO:0034178) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway (GO:0034162) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 7 signaling pathway (GO:0034154) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 5 signaling pathway (GO:0034146) [is_a relation] is_a  toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway (GO:0034130) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 11 signaling pathway (GO:0034170) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 3 signaling pathway (GO:0034138) [is_a relation] is_a  toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway (GO:0034123) [RO:0002213 relation] RO:0002213  toll-like receptor signaling pathway
None.