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Term Information

Accession
GO:0002102
Name
podosome
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. Source: PMID:15890982, PMID:12837608
Comment
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
History
See term history for GO:0002102 at QuickGO
Subset
None
Feedback
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Graph of GO:0002102

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Parents of podosome (GO:0002102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
podosome [is_a relation] is_a  intracellular non-membrane-bounded organelle (GO:0043232)
podosome [BFO:0000050 relation] BFO:0000050  actin cytoskeleton (GO:0015629)
Children of podosome (GO:0002102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
podosome core (GO:0061825) [BFO:0000050 relation] BFO:0000050  podosome
podosome ring (GO:0061826) [BFO:0000050 relation] BFO:0000050  podosome
Wikipedia
Podosome