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Term Information

Accession
GO:0000398
Name
mRNA splicing, via spliceosome
Ontology
biological_process
Synonyms
nuclear mRNA splicing, via spliceosome, splicing AT-AC intron, splicing GT-AG intron, nuclear mRNA splicing via U12-type spliceosome, nuclear mRNA splicing via U2-type spliceosome, mRNA splicing, pre-mRNA splicing
Alternate IDs
GO:0006374, GO:0006375
Definition
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. Source: GOC:krc, ISBN:0198506732, ISBN:0879695897
Comment
Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
History
See term history for GO:0000398 at QuickGO
Subset
None
Feedback
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Graph of GO:0000398

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Parents of mRNA splicing, via spliceosome (GO:0000398)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mRNA splicing, via spliceosome [is_a relation] is_a  mRNA processing (GO:0006397)
mRNA splicing, via spliceosome [is_a relation] is_a  RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)
Children of mRNA splicing, via spliceosome (GO:0000398)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of mRNA splicing, via spliceosome (GO:0048024) [RO:0002211 relation] RO:0002211  mRNA splicing, via spliceosome
spliceosomal snRNP assembly (GO:0000387) [BFO:0000050 relation] BFO:0000050  mRNA splicing, via spliceosome
mRNA cis splicing, via spliceosome (GO:0045292) [is_a relation] is_a  mRNA splicing, via spliceosome
alternative mRNA splicing, via spliceosome (GO:0000380) [is_a relation] is_a  mRNA splicing, via spliceosome
positive regulation of mRNA splicing, via spliceosome (GO:0048026) [RO:0002213 relation] RO:0002213  mRNA splicing, via spliceosome
spliceosomal complex assembly (GO:0000245) [BFO:0000050 relation] BFO:0000050  mRNA splicing, via spliceosome
mRNA trans splicing, via spliceosome (GO:0000365) [is_a relation] is_a  mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome (GO:0048025) [RO:0002212 relation] RO:0002212  mRNA splicing, via spliceosome
spliceosomal conformational changes to generate catalytic conformation (GO:0000393) [BFO:0000050 relation] BFO:0000050  mRNA splicing, via spliceosome
spliceosomal complex disassembly (GO:0000390) [BFO:0000050 relation] BFO:0000050  mRNA splicing, via spliceosome
None.