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Term Information

Accession
GO:0000178
Name
exosome (RNase complex)
Ontology
cellular_component
Synonyms
exosome (ribonucleasease complex), exosome multienzyme ribonuclease complex
Alternate IDs
None
Definition
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. Source: PMID:26726035, PMID:17174896, PMID:20531386
Comment
Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
History
See term history for GO:0000178 at QuickGO
Subset
goslim_pir
Feedback
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Graph of GO:0000178

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Parents of exosome (RNase complex) (GO:0000178)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
exosome (RNase complex) [BFO:0000050 relation] BFO:0000050  intracellular anatomical structure (GO:0005622)
exosome (RNase complex) [is_a relation] is_a  exoribonuclease complex (GO:1905354)
Children of exosome (RNase complex) (GO:0000178)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear exosome (RNase complex) (GO:0000176) [is_a relation] is_a  exosome (RNase complex)
cytoplasmic exosome (RNase complex) (GO:0000177) [is_a relation] is_a  exosome (RNase complex)
None.