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Term Information

Accession
GO:0000176
Name
nuclear exosome (RNase complex)
Ontology
cellular_component
Synonyms
eukaryotic exosome multienzyme ribonuclease complex, nuclear exosome (ribonuclease complex), nuclear exosome multienzyme ribonuclease complex
Alternate IDs
None
Definition
A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. Source: PMID:26726035, PMID:17174896, PMID:20531386
Comment
None
History
See term history for GO:0000176 at QuickGO
Subset
None
Feedback
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Graph of GO:0000176

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Parents of nuclear exosome (RNase complex) (GO:0000176)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear exosome (RNase complex) [is_a relation] is_a  exosome (RNase complex) (GO:0000178)
nuclear exosome (RNase complex) [BFO:0000050 relation] BFO:0000050  nucleus (GO:0005634)
nuclear exosome (RNase complex) [BFO:0000050 relation] BFO:0000050  nuclear lumen (GO:0031981)
Children of nuclear exosome (RNase complex) (GO:0000176)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear exosome focus (GO:1990251) [BFO:0000051 relation] BFO:0000051  nuclear exosome (RNase complex)
nucleolar exosome (RNase complex) (GO:0101019) [is_a relation] is_a  nuclear exosome (RNase complex)
None.